This refers to the novel Frankenstein by Mary Shelley. In this novel, we see that the acquisition of knowledge by Victor brings serious negative consequences to the story. Victor is obssessed with the idea of gaining scientific knowledge. This is what ultimately pushes him to create the creature. However, this pursuit of knowledge causes him to lose everything he has, even his life.
Sometimes, the acquisition of knowledge has negative consequences in our society. For example, new knowledge has often led to the development of new technology. This technology (for example, cell phones) has caused us to consume more, creating more waste and pollution from production and thus damaging the environment. The new knowledge creates an unhealthier world that is worse than the "simpler" world of less knowledge.
